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This process contributes to cellular and tissue damage in various human diseases, such as cardiovascular diseases, neurodegeneration, liver disease, and cancer

Oncoimmunology (2016) 5(5):e1122860.10.1080/2162402X.2015.1122860 62 Sunden-CullbergJNorrby-TeglundARouhiainenARauvalaHHermanGTraceyKJet alPersistent elevation of high mobility group box-1 protein (HMGB1) in patients with severe sepsis and septic shock

33 Dihexa plasma levels after intrao vascular (IV) infusion

doi: 10.1073/pnas.1501555112 22 PelicanoHZhangWLiuJHammoudiNDaiJXuRHet al

This ongoing neuroinflammatory activity appears to play a central role, not only in perpetuating cognitive deficits similar to those seen in dysexecutive syndrome but also in contributing to widespread dysregulation across brain networks, which is a characteristic of the brain fog frequently reported in these patients [49,50]