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Here, insulin resistance directly correlates with hepatic de-novo lipogenesis (DNL) [57], which has been shown to significantly contribute to IHLC in lean individuals without NAFLD (~11%), but being even more pronounced in obese individuals (~19%) and obese NAFLD patients (~38%)

doi: 10.1016/b978-0-12-420117-0.00008-6 131 HasegawaYTakanoTMiyauchiAMatsuzukaFYoshidaHKumaKet al

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doi: 10.1186/1475-2891-13-79 63