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melanotic macule. Benign. Dark spot on labia (or lip). Analogous to lentigo simplex. Hyperpigmented basal keratinocytes & dermal melanophages. Slight ⬆️ in single basal melanocytes; NO nests. More info like this in Oral Melanotic Macule: Symptoms and
Description
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Giant ceribriform intradermal nevus on the back of a newborn

At 0.5mg, MC4R occupancy is partial

Some of the causes can include bleeding from the bowel, often from diverticulosis, angiodysplasia (abnormal and leaky blood vessels in the intestinal lining) or bowel cancer
No two individuals respond to peptide therapy exactly the same way
