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In renal I/R injury models, the expression of ERS-related proteins such as IRE1, XBP1, and GRP78 is significantly increased (104), and miR-124 can bind to the 3UTR of IRE1, downregulating IRE1 expression and inhibiting the IRE1/XBP1 pathway, reducing ERS and apoptosis, and thus alleviating renal I/R injury (104)

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In addition, EA was found to have poor low oral bioavailability, thus limiting its clinical applications
Consistently, XKR8 KO neutrophils released significantly less extracellular double-stranded DNA (dsDNA) in the culture medium compared to WT controls during NET formation (Extended Data Fig

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