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The resistant cells, however, were insensitive to a physical mixture of equimolar doxorubicin and oxaliplatin, implicating the need for covalent incorporation of platinum (Fig
For these authors, successful therapy requires both, DNA demethylation and triggering activating histone modifications, to induce complete gene expression of epigenetically silenced genes and depsipeptide fulfills both criteria (Hauptstock et al., 2011)
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Follow the treatment schedule recommended by your provider
Metabolic bioactivation as a pathogenic mechanism
High risk and low prevalence diseases: Serotonin syndrome
