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The antimalarial drugs and divicine, the active ingredient of fava beans, share the common property of exposing the cells of the body to oxidative stress, from the elevated production of reactive oxygen intermediates

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1 Among various types of stem cells, mesenchymal stem cells (MSCs) have garnered significant interest because of their unique biological properties, versatility, and clinical safety profile

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Neurotoxicology 60, 274279

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While resistant cells upregulate the System Xc - -GSH-GPX4 axis to counteract oxidative stress (e.g., SLC7A11 overexpression in lung cancer), this defense is inherently fragile ( - activity is suppressed by CD8 + T cell-derived IFN (via JAK/STAT-mediated SLC7A11 downregulation), and (46)

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Zou et al., 2020

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