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Hart LL, et al

Simultaneously, ROS activates MAPKs such as p38 and JNK, increasing the expression of inflammatory mediators and MMPs, which accelerate BBB breakdown (Figure 3) [191,192]

Stomach acid drops with age, intrinsic factor production drops with it, and dietary B12 absorption follows

Catechin and its derivatives are the main functional components in tea and many studies have shown that the effects of catechin on mitochondria-related pathways can prevent neurodegeneration and delay the decline of brain function ( Caenorhabditis elegans strains that express amplified ATX3 (amyloid) toward non-toxic aggregation and prevent calcium influx-mediated cytotoxicity of nerve cells (Visentin et al., 2017)