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Ann NY Acad Sci 973:488504 Farid A, Shah AH, Ayaz M, Amin A (2012) Comparative study of biological activity of glutathione, sodium tungstate and glutathione-tungstate mixture

Key points GLP-1 is a hormone that increases insulin release and prevents the release of too much glucagon, helping manage blood glucose levels in individuals with type 2 diabetes GLP-1 receptor agonists, such as liraglutide and semaglutide, effectively reduce blood glucose levels Semaglutide is more effective than liraglutide at reducing blood sugar levels Tirzepatide is a newer GLP-1 receptor agonist that also mimics the actions of another hormone called GIP, which can also reduce blood sugar levels A randomised controlled trial showed that tirzepatide led to more significant blood sugar reductions than semaglutide across three doses Tirzepatide may be more effective than semaglutide at higher doses, but this needs further investigation Liraglutide and semaglutide are available in the UK and the US, while tirzepatide is only available in the US but is likely to be approved in the UK soon

IGF-1 exerts negative feedback inhibition of GH and GHRH at the anterior pituitary and hypothalamus, respectively (dashed arrow)

In this context, targeting CoQ 10 oxidoreductases may represent a more clinically tractable strategy