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VGF is a neurosecretory protein that primarily functions via its downstream proteoforms, with putative roles in metabolic regulation, A clearance and synaptogenesis 48,49,50

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The consistency of the safety profile across short-term and long-term trials suggests that AOD-9604 does not produce cumulative toxicity or delayed adverse effects that emerge only with chronic administration

Research models have observed DSIPs interaction with pathways associated with cortisol regulation, neurotransmitter balance, and adaptive stress response, highlighting its relevance in sleep and cognition-focused research