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Life Sci 311:121184 Sahay RK, Mittal V, Gopal GR et al (2020) Glimepiride and metformin combinations in diabetes comorbidities and complications: real-world evidence

Although emerging strategies such as C5aR antagonists or CR2-CD59 fusion proteins have demonstrated in animal models the ability to achieve tissue-specific inhibition by targeting the C5a-C5aR axis, thereby reducing inflammatory damage while preserving physiological complement functions (143), their clinical translation is still hampered by difficulties in target validation, substantial inter-individual variability in response and a lack of long-term safety data

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Chem Commun (2017) 53(13):21225

K., Psychological Flexibility as a Resilience Factor in Individuals with Chronic Pain, Frontiers in Psychology 10 (2019): 2016