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The continued influx of acetylcholine causes catatonia (repetitive motions) to the point of exhaustion and a comatose state

In Quebec, where one in four adults is obese, the current cost of these new drugs (approximately $500 per month) would involve an annual expenditure of several hundred million dollars (in the United States the situation is even worse: the cost of a 72-week course of tirzepatide (15 mg/week) is approximately US$17,000, while the 68-week treatment with semaglutide (2.4 mg/week) is nearly US$23,000!)

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274 Another significant compound, guadecitabine (SGI110, an antimetabolite of decitabine), represents a second-generation DNA methylation inhibitor

[PubMed: 23831306] 612