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Braumuller, H

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Many people begin to notice reduced pain and improved joint function within 2 to 4 weeks of starting BPC-157

showed that Hif-2 deficiency in mice enhances bone mass, partially because HIF-2 directly induces RANKL expression in osteoblasts leading to increased osteoclastogenesis 8

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However, when this study was repeated by a different group, the results could not be replicated, and the investigators concluded that this therapy lacked efficacy in this patient population [396]
