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Especially for those who cannot absorb all of the B12 they ingest due to an underlying condition like inflammatory bowel disease, says Mary Wirtz, a nutrition consultant for Mom Loves Best

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Methylcobalamin is another non-prescription form popular in wellness settings, with more limited clinical evidence than hydroxocobalamin for treating true deficiency

Adamia and colleagues have identified alternate splice variants of CD38 that abrogate the binding sites for antiCD38 antibodies

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However, older patients, commonly those older than 65 years, often present with vague or atypical symptoms in conditions associated with vitamin B12 deficiency [6]