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COPD progression is another complex process, explaining why targeting of single pathways may be insufficient in halting the disease Declaration of Interest Dr

Hyungseok Lee: Supervision, Project administration, Funding acquisition

When that occurs, the body cannot break down fat as well as it should

10.1016/j.yjmcc.2013.11.017 187 PenaO

Upon ligand binding, PPAR-alpha undergoes a conformational change and associates with the nuclear receptor of 9- cis retinoic acid (RXR), forming a heterodimer that binds to PPAR-alpha responsive elements in the promoter of multiple genes associated with fatty acid metabolism, such as CPT1 (beta-oxidation), DECR2 (unsaturated fatty acid synthesis), ACAA1 (peroxisomal fatty acid oxidation) and ACADVL (beta-oxidation of very-long chain fatty acids) [23]

To characterize the membrane properties of neurons, hyper- and depolarizing current steps were applied for 1 second in 20-pA increments from 100 pA to 200 pA