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Diverse genetic causes of polymicrogyria with epilepsy

By regulating mitochondrial TML availability, SLC25A45 links environmental stressors such as cold exposure and fasting to adaptive fuel switching toward fatty acid oxidation, thereby optimizing mitochondrial energetics and metabolic resilience

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This mTOR-driven anabolic shift, while adaptive in peripheral nerves, exhibits divergent outcomes in the central nervous system, where chronic mTORC1 activation in astrocytes drives pathological lipid synthesis and droplet accumulation via DGAT1/PLIN2 upregulation, directly linking mTOR to maladaptive glial reactivity and impaired recovery in chronic stroke phases [35, 189]

Studies have indicated that it may protect brain cells from oxidative stress and reduce age-related decline in brain function

As we get older, our arteries change, leading to more plaque