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J Cell Biochem 59:2432

As renal function declines, microbial diversity decreases, with a reduction in beneficial butyrate-producing bacteria and an expansion of uremic toxinproducing anaerobes such as indole- and p-cresolgenerating strains (45)

Glutathione helps neutralize these threats and support lasting cellular integrity

Both cytosolic and peroxisomal isoforms of Cu/Zn-SOD rely on zinc for stability and activity, and MTs serve as zinc buffers, releasing zinc under oxidative stress to fine-tune redox signaling and enzyme expression 94

MT, SA, and DS analyzed the diet data

Expression of antioxidant genes, including Gsta, Mgst, Sod, and Gsr, was upregulated, while Western blot analyses showed enhanced glucose metabolism in aged chickens receiving fisetin [96]