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Finally, while rodent models demonstrate compelling proof-of-concept (e.g., SCFA supplementation ameliorates OA), the translatability of these findings to human physiology, with its greater complexity and longer disease course, is a significant hurdle that future research must overcome (30)

doi: 10.1016/j.jpba.2017.11.054 268 CittiCCiccarellaGBraghiroliDParentiCVandelliMACannazzaG

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While his chest pain was relieved by nitroglycerin, administered as a coronary artery dilator, his cardiac evaluation showed no vascular abnormality

Alternatively, consider the use of non-opioid analgesics in these patients

It is important to note that few studies have examined omics biomarkers in relationship to existing clinical criteria, such as coma or a constellation of clinical and laboratory findings (i.e., Kings College Criteria) currently in use by clinical practitioners as a prognostic indicator