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doi: 10.3389/fphar.2023.1303207 Received 27 September 2023 Accepted 31 October 2023 Published 04 December 2023 Volume 14 - 2023 Edited by Francisco Lopez-Munoz, Camilo Jos Cela University, Spain Reviewed by Christopher Freet, The Pennsylvania State University, United States Marilia Gag Pereira, Federal University of Alfenas, Brazil Updates Copyright 2023 Bates, Getsy, Coffee, Baby, MacFarlane, Hsieh, Knauss, Bubier, Mueller and Lewis

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It was revealed that Vit C increases to induce midbrain-derived neural stem cells into dopaminergic neurons by increasing 5-hydroxymethylcytosine and decreasing histone H3 lysine 27 tri-methylation generation in the dopamine phenotype gene promoters, which are catalyzed by ten-eleven-translocation 1 (Tet1) methylcytosine dioxygenase 1 and histone H3K27 demethylase (Jmjd3), respectively