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Exhaustion from a lack of sleep is a contributing, if not a causative factor in MS fatigue

Post-mortem and imaging studies further reveal deficits in electron transport chain complexes and pyruvate dehydrogenase activity, suggesting a mechanistic link between mitochondrial bioenergetics and ASD-related phenotypes

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[40] Bryan NS, et al

It has been found to relieve cancer-associated fatigue, as well as chemotherapy-induced neuropathy
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