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Among these, polyphenols (163), flavonoids (164) and certain herbs (165) along with other phytonutrients (166) have demonstrated therapeutic benefits in neurologic disorders

They play diverse roles, from improving tight junction expression to modulating immune function and exerting regulatory effects on organ-specific systems through gut-organ axes

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Based on the well-known reaction mechanisms of ozone, with its biochemical and pharmacological effects partly shown here, international guidelines have been defined concerning physiological and ozone resistant materials, indications, applications, and the effective concentration and dosage range depending on specific indications

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