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Therefore, bi-directional causal effects were observed, and instances of true bi-directional pathway might exist, and in other words, a proposed positive effect of vitamin B12 on NAFLD risk, whereas NAFLD also exerts a positive effect on vitamin B12, possibly as part of a positive feedback loop

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For instance, BVR has been shown to be a member of the insulin receptor substrate family (Lerner-Marmarosh et al., 2005) with pleiotropic functions that include effects on metabolism and cytoprotection (Kapitulnik and Maines, 2009)

10.1016/j.jdermsci.2010.10.016 15

Bifidobacterium longum and Lactobacillus helveticus synergistically suppress stress-related visceral hypersensitivity through hypothalamic-pituitary-adrenal Axis modulation