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Manipulating VIT levels has been shown to affect the lifespan by altering autophagy [12]

Toxicol Res Appl 5:23978473211005562 Mateus FG, Moreira S, Martins AD, Oliveira PF, Alves MG, Pereira MDL (2023) L-carnitine and male fertility: is supplementation beneficial

The principal methylations associated with gene activation are H3K4, H3K36, and H3K79

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Second, clinical and pre-clinical studies showed that mutations that reduced CETP function were associated with higher HDL levels, increased reverse cholesterol transport, lower LDL levels and reduced cardiovascular events

This process was initially described in algae [400] and has been later extended to non-homeothermic animals