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Building on the essential role of SLC25A45 in TML transport, the authors explored the structural basis for its mechanistic function

PGC-1 is a transcription cofactor that has been shown to be a potent activator of mitochondrial biogenesis

251 In a randomized placebo-controlled trial with 28 female participants with fibromyalgia, those who received creatine, at 5 grams four times daily for five days followed by 5 grams daily for the remainder of 16 weeks, had greater increases in muscle phosphocreatine stores and strength than those who received placebo, although no differences in fibromyalgia symptoms were detected

It also increases endurance and intensity

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Anal Lett (1971) 4(3):15160