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Researchers used small-molecule ligands (i.e., folate, class A scavenger, and galactose) for the modification of nanodrugs to target a variety of specific receptors that are overexpressed on the surface of macrophages, such as folate receptors (FRs), class A scavenger receptors (SR-As), and galactose receptors (Pirmardvand Chegini et al., 2018)

Nature 436 , 588592 (2005)

Embodiment 169 A method of reducing tumor initiating cells in a cell population, the method comprising contacting a cell population, wherein the population comprises tumor initiating cells that express ALPPL2 and cells other than tumor initiating cells, with an anti-ALPPL2 immunoconjugate according to any one of embodiments 136- 164, wherein the effector comprising said immunoconjugate has cytostatic and/or cytotoxic activity and/or immunomodulatory activity, whereby the frequency of tumor initiating cells in the tumor cell population is reduced

Providing your body with the right building blocks, supporting the enzymes that synthesize glutathione, and reducing oxidative stress that depletes it

April 2016;43:1-6

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