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Hogendorf, Thomas E

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Due to its important role in cancer progression, TrxR is becoming an attractive target in chemotherapeutic drug design

A drug was given to a patient by simultaneous administration of a loading dose of 10 mg and an infusion rate of 2 mg/hr (the drug has a 1/2 of 3 hr and a volume of distribution of 10 L)

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This diffusible intracellular 2nd messenger in turn is an activating ligand for the cytoplasmic enzyme, cAMP-dependent protein kinase (PKA)