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As a consequence, the unrestrained and potentially lethal accumulation of ROS threatens to damage many biomolecules: lipids, proteins, DNA, and host cells

C5L2 ligand binding induces their internalization and degradation, which decreases their extracellular expression level, which is a step to decrease the generation of profound or tissue-damaging complement-mediated inflammatory immune response (241)

In addition, recent studies suggest that under certain conditions, such as hyperreduced CoQ pools and elevated mitochondrial membrane potential, reverse electron transport may occurwhereby electrons flow from ubiquinol (CoQ 10 H 2 ) back to complex I, generating NADH 110,111

Chen T, Wu F, Wang X, Ma G, Xuan X, Tang R, et al

DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING

However, no significant difference in reduced glutathione level was observed, which suggested that L-glutathione quenched the ROS by increasing the enzymatic antioxidant (SOD) level