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[PMC free article] [PubMed] [Google Scholar] Aliev G., Liu J., Shenk J.C., Fischbach K., Pacheco G.J., Chen S.G., Obrenovich M.E., Ward W.F., Richardson A.G., Smith M.A., Gasimov E., Perry G., Ames B.N

It had a tumor capsule containing collagen fibers (Figure 4A) and was composed of necrotic tissue, most of which was melanin and melanophage (Figure 4B and 4C)

However, patients without hepatic metastasis had better ORR than patients with hepatic metastasis, indicating that ipi/nivo alone is not enough for LMUM [89]

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8 Laboratory testing may be necessary to rule out an underlying endocrinopathy

Koizumi A, Nozaki J, Ohura T, Kayo T, Wada Y, Nezu J, Ohashi R, Tamai I, Shoji Y, Takada G, Kibira S, Matsuishi T, Tsuji A: Genetic epidemiology of the carnitine transporter OCTN2 gene in a Japanese population and phenotypic characterization in Japanese pedigrees with primary systemic carnitine deficiency