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Investigations showing cognitive/behavioral deficits caused by charged particles (relevant for protection against space radiation) in rodent models were carried out to understand the possible limitation to human exploration of our solar system [235,236]

For instance, we also found abnormal connectivity in areas of the anterior temporal network, including the hippocampus and the temporal pole 36

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Furthermore, high glucose upregulates the TGF-/Smad3 signaling pathway, promoting podocyte EMT and extracellular matrix (ECM) deposition, thereby exacerbating glomerular injury (Yasuda et al., 2021)