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A brain and microglia dual targeting nanosystem was constructed by an targeting peptide derived from -amyloid protein and ROS-responsive amphiphilic polymer

10.1056/NEJM200103083441001 10 BertozziG.FerraraM.Di FazioA.MaieseA.DeloguG.Di FazioN.et al (2024)

The Pislyagin team employed radioisotopic tracing (using a 3 H-labeled compound and liquid scintillation counting), MALDI-MS, and MALDI-MSI technologies (with CHCA as the matrix) to systematically analyze the stability and dynamic changes of the triterpene glycoside cucumarioside A 2 -2, the main compound of the medical lead compound Cumaside for use in immunodeficiency diseases, in the spleen tissue of mice

Sublingual or intranasal administration increases bioavailability to 6080%, allowing lower nominal doses to match the CNS exposure of higher oral doses