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C 112 (6), 18511856 (2008) W

In this case, the enzyme -glutamylcyclotransferase catalyzes the conversion of -glutamyl-L-cysteine to 5-oxoproline, favoring the occurrence of 5-oxoprolinuria, chronic metabolic acidosis and neurological disorders (Figure 2) [22]

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2,11 Therefore, the AAN states, There is insufficient evidence to make recommendations regarding the use of facial nerve decompression to improve facial functional outcomes(level U recommendation)

Toxicology studies have shown no lethal dose (LD1) could be achieved in animal models, suggesting a wide therapeutic window
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