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Description
The REDEFINE protocol escalated the dose over 16 weeks (0.25 0.5 1.0 1.7 2.4 mg), so the full pharmacologic dose was not reached until roughly week 17

232,233,241,259 (Fig

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Toxicity evaluation According to a patent, "Short duration safety studies with Dihexa have uncovered no apparent toxicity

A good example is the finding that low circulating levels of IGF-1 are independently associated with hyperglycaemia and insulin resistance in adults [160, 230232]

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