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Oral approaches are discussed for ease of use and certain preferences, while injectable approaches are discussed for tissue targeting and bioavailability considerations

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doi: 10.1210/jcem.86.10.7885 31 StengelATachI

At 10 -8 M, no proliferative effect was observed consistent with the follicle results

Such translational biomarkers provide a link between preclinical models and human clinical trials, facilitate dose selection, speed up clinical therapeutic development, provide early clinical proof-of-concept and are now seen as critical parameters for successful drug development [4]

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