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Patients with a history of cobalt allergy may be at increased risk, as all cobalamins (including hydroxocobalamin and cyanocobalamin) contain a cobalt atom in their molecular structure

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That may be due to a genetic difference in their ability to convert inactive T4 to T3, the active form

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One of the antigens identified, metE, conferred significant protection against MTB in mice when delivered as a protein/adjuvant vaccine candidate, suggesting its potential for inclusion in the next-generation of TB vaccines