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Interestingly, intervention studies suggest that synbiotic combinationsprebiotic fiber plus probiotic strains such as Bifidobacterium and Lactobacillusmay help reduce circulating TMAO-producing taxa while enriching beneficial commensals (e.g., Bifidobacterium, Akkermansia) and thus decrease systemic TMAO levels [44,45,46].Hepatic FMO3 inhibition represents another target, though it carries the risk of accumulating TMA, which can cause trimethylaminuria and related toxicities [47]

439 FAs also impact the response to cancer immunotherapy