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In the future, with increased scientific research investment, its application scenarios will be further expanded

PLoS ONE 10, e0130908

This 'first-pass effect' exposes the compound to hepatic enzymes

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Mizuno R, Hojo H, Takahashi M, Kashio S, Enya S, Nakao M, Konishi R, Yoda M, Harata A, Hamanishi J (2022) Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide- N -methyltransferase