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doi: 10.1104/pp.110.153601 30 SkipseyM.KnightK

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Assays performed using a fully complementary target RNA and an AGO2 active-site variant (D669A, to prevent slicing of fully complementary target RNA) showed weak binding to ZSWIM8 and polyubiquitylation activity intermediate between that of the seed-only and trigger RNAs (Extended Data Fig

KPV peptide is non-toxic and well-tolerated , even with prolonged use

Neurturin, a relative of glial-cell-line-derived neurotrophic factor