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One thing that could cause this decline is a decrease in blood flow through your body, a process called intermittent claudication

However, a common limitation of probiotics used to lower TMAO levels and potentially reduce the risk of atherosclerosis is that the effect of treatment may change according to the gut microbiota composition of each specific individual

There were studies that mainly researched 4-5 stage CKD, few about 13 stage CKD (Hu et al., 2022)

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The mechanism through which these ingredients act probably occurs in the following manner: the biologically active ingredients in traditional Chinese medicine alter the structure of the intestinal flora, the endogenous metabolites produced by some traditional Chinese medicines with the participation of the intestinal flora play an anti-inflammatory and anti-AS effect, Chinese medicine adjusts the intestinal flora imbalance caused by AS to improve AS

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