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Chronic Autoimmune ThyroiditisA General Overview Genetic and environmental factors are known to be involved in the pathogenesis of chronic autoimmune thyroiditis [3], whereas epigenetics factors [16] are also indicated as important players in the development of the disease

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Widespread use of certain herbicides containing TCDD, other dioxins, and DLCs, as well as some types of industrial emissions, resulted in local and global contamination of air, soil, and water with trace levels of these compounds

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Inflammatory intensity was also confirmed with increased mRNA expression of inflammatory mediators, TNF- and interleukin (IL)-1 and worsening of macroscopic scores