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In DR, oxidative stress also influences DNA methylation [64], Aberrant methylation of key genes involved in the inflammatory response in the retina has been observed

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doi: 10.1152/ajpendo.00347.2016

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Male SD rats were administered a single IM injection of blank solvent (excipient), and biological samples, including whole blood, plasma, urine, feces, and tissues, were collected for background control

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