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In contrast, overactivation of NMDAR by NMDA agonists increases the cytosolic concentrations of calcium and zinc, which significantly contributes to neural death, an effect known to be prevented by cannabinoids, mediated by activation of the CB 1 receptor, which leads HINT1 protein to counteract the toxic effects of NMDAR-mediated NO production and zinc release

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[PubMed] [Google Scholar] 41.Gamulin O., Serec K., Bilic V., Balarin M., Kosovic M., Drmic D., Brcic L., Seiwerth S., Sikiric P