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This phenomenon may help explain the obesity paradox, which suggests that, even though people who are obese are at greater risk of developing heart issues, once heart disease develops, individuals with higher BMIs appear to have a lower mortality risk than people with normal BMIs

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doi: 10.1016/j.exger.2010.08.028

Post-mortem studies of brains from patients with HD have shown increased levels of DA and increased activity of tyrosine hydroxylase (TH), the rate-limiting enzyme in DA synthesis, in the striatum and SNc 3,4,5

Indeed, a study done with the fluorescent probes with an enhanced sensitivity to NO demonstrated that low NO and iNOS levels in PBMC from HIV-infected patients correlate with enhanced viral replication [221]