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Lockley SW, Skene DJ, Arendt J, Tabandeh H, Bird AC, Defrance R

This figure illustrates the multifactorial pathogenesis and sequential progression of metabolic dysfunction-associated steatotic liver disease (MASLD), starting from simple hepatic steatosis and advancing to metabolic dysfunction-associated steatohepatitis (MASH), fibrosis, and ultimately cirrhosis

Apart from the involvement of hippocampus in memory, a decreased functional connectivity between amygdala and hippocampus and an increased connectivity between amygdala and dorsolateral prefrontal cortex observed in older adults in learning emotion-based memory 34

Phillips PS, Haas RH, Bannykh S, Hathaway S, Gray NL, Kimura BJ, Vladutiu GD, England JD

For example, AMPK-activating mimetics (such as AICAR or metformin) have been experimentally combined with mTOR inhibitors (e.g., rapamycin) to reduce kidney tumor size in a nude mouse model [324]