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PI3K/Akt/mTOR signaling pathway: a dysregulated regulatory hub The PI3K/Akt/mTOR pathway plays a critical, albeit contrasting, role in follicle activation and luteal function

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In the United States alone, the annual cost of PD exceeds $52 billion, including direct medical expenses and indirect costs such as lost productivity and caregiver burden ( This review synthesizes contemporary insights into PDs pathophysiology, genetic and environmental risk factors, comorbidities, and therapeutic innovations