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Ghodsi, Z., Kalbassi, M.R., Farzaneh, P., Mobarez, A.M., Beemelmanns, C., and Amiri, M.J., Fish Shellfish Immunol

"Lowering homocysteine with B vitamins has no effect on biomarkers of bone turnover in older persons: a 2-y randomized controlled trial"

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A detailed family history regarding fertility, as well as the use of androgenic or estrogenic substances during pregnancy, maternal virilization during pregnancy, and information about procreation may be helpful

The AAFPs evidence-based clinical review states directly: Oral administration of high-dose vitamin B12 (1 to 2 mg daily) is as effective as intramuscular administration for correcting anemia and neurologic symptoms in patients with B12 deficiency (Langan RC, Goodbred AJ, American Family Physician, 2017)