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Its core pathogenesis lies in the synergistic interaction between genetic susceptibility (e.g., gene variants) and environmental triggers (e.g., ultraviolet radiation and gut microbiota dysbiosis), leading to multiple immune system disorders
"Methylation of nicotinamide with soluble enzyme system from rat liver (in Eng)
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An association with vitamin B 12 deficiency in non-metformin-exposed individuals and genotype was also demonstrated for both AG (OR 1.11 [95% CI 0.99, 1.24], I 2 =19.3%) and AA (OR 1.42 [95% CI 1.21, 1.67], I 2 =14.4%) genotypes but ORs were lower than in metformin-exposed individuals

B12 plays an essential role in enhancing the metabolic function of the cells, this nutrient can boost energy, improve memory and help prevent heart disease
