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Ly et al

We thus hypothesize that less MG is produced in tumors by concomitant lower oxidation of DHAP/G3P to MG, due to a more efficient lower glycolysis with highly active serine de novo/glutathione synthesis and active TCA, reducing the pool of available DHAP/G3P for MG formation

Topoisomerase inhibition complements these mechanisms through copper-mediated DNA intercalation and catalytic interference

However, individuals with absorption issues, dietary restrictions (such as vegans), or certain medical conditions may benefit more from injections, as they bypass the digestive system for direct absorption

Rev Endocr Metab Disord 2008;9:203-11

CYP2D6 Metabolism and Pharmacogenomic Variability The liver converts hydrocodone to hydromorphone via CYP2D6 O-demethylation, producing an active metabolite with approximately 30 times higher mu-opioid receptor affinity than the parent compound