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Other studies in mice demonstrated that lipopolysaccharides treatment induced neuroimmune gene expression, NOX activity, and oxidative stress that persisted for at least 20 months and led to neurodegeneration [134]

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In addition, the hydrazone and oxime linkages are inherently unstable, leading to hydrolysis over the course of hours, particularly under acidic conditions, although hydroxylamines are reported to generate more stable linkages 160

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[DOI] [PMC free article] [PubMed] [Google Scholar] 44.Franco R., Cidlowski J.A