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Rapid growth behavior would indicate intervention for study purposes, lesions that are stable for more than 4 to 5 years are only indicated for removal for aesthetic purposes
The dermis and subcutaneous tissue are both part of an organ system, so, once a substance passes the epidermis, the potential risk of systemic complications increases
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(PubMed) Scarpini E, Sacilotto G, Baron P, Cusini M, Scarlato G
