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270 Furthermore, with the progression of renal injury, the expression levels of canonical Wnt pathwayrelated genes Fn1, Cd44 , Mmp7 , and Nos2 were upregulated, and so were those of the Wnt/Ca 2+ pathwayrelated genes Prkcb1 , Prkch , Nfact1_pred , and Nfact2

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In in vitro granuloma models, everolimus not only controlled M.tb growth but also demonstrated an additive effect when combined with front-line anti-TB drugs like isoniazid and pyrazinamide

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