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ADDITIONAL RESEARCH & SCIENTIFIC DATA

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Chondrocyte dedifferentiation was majorly characterized as the reduced expression of COL2 and ACAN and enhanced expression of type I collagen and versican ( COL2 expression, but not ACAN ( In addition to dedifferentiation, another consequence of in vitro expansion is replicative senescence, which also significantly influences chondrocyte function

There was no significant survival difference between high M1/M2 ratio tumors compared with low M1/M2 ratio tumors except DFS in TNBC (Supplementary Fig